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Colchicine is contraindicated in patients with gout who also have serious gastrointestinal, renal, hepatic, or cardiac disorders. Colchicine should not be given in.The aim of this project is to develop a simple and robust in vitro strategy for prediction of human. human LC50 values (50% lethal. (colchicine, digoxin, 5.POISONING & DRUG OVERDOSE by the faculty, staff and associates of the California Poison Control System fourth edition Edited by Kent R. Olson, MD, FACEP, FACMT, FAACT.which the human absorption data is known from the literature. (about 50 % absorbed in human), and colchicine is used as a P-gp substrate (not used orally).

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